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Sigma
Azoxymethane
A2853 -
Practical grade, 13.4 M, ≥90% (GC)
DOWNLOAD MSDS (PDF)Synonym: AOM
CAS Number: 25843-45-2
Linear Formula: CH3N=N(→O)CH3
Molecular Weight: 74.08
MDL number: MFCD00126912
PubChem Substance ID: 24890698
Properties
| Related Categories | Cancer Research, Carcinogens |
| assay | ≥90% (GC) |
| quality | Practical grade |
| contains | ≤15% ethanol and acetic acid (Packaged based on azoxymethane.) |
| composition | methylene chloride, ≤5% (solvent) |
| concentration | 13.4 M |
| bp | 97-99 °C(lit.) |
| density | 0.991 g/mL at 25 °C(lit.) |
| storage temp. | −20°C |
Description
Frequently Asked Questions
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Biochem/physiol Actions
Carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.
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Safety Information
| Symbol |    GHS02, GHS06, GHS08 |
| Signal word | Danger |
| Hazard statements | H226-H300-H315-H319-H350 |
| Precautionary statements | P201-P264-P301 + P310-P305 + P351 + P338-P308 + P313 |
| Personal Protective Equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
| Hazard Codes | T |
| Risk Statements | 45-46-10-25-34 |
| Safety Statements | 53-26-36/37/39-45 |
| RIDADR | UN 1992 3/PG 3 |
| WGK Germany | 3 |
| Flash Point(F) | 75.2 °F |
| Flash Point(C) | 24 °C |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
Articles
Carcinogenesis and Epigenetics
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Transcription, transformation
DNA Damage and Repair
Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, PAGE, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription
References
Bissahoyo, A., et al. , Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet. Toxicol. Sci. 88, 340-345, (2005)
Suzuki, R., et al., Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis 27, 162-169, (2006)
Reddy, B.S., Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. Environ. Mol. Mutagen. 44, 26-35, (2004)
Takahashi, M. and Wakabayashi, K. , Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci. 95, 475-480, (2004)
Hong, M.Y., et al., Anatomical site-specific response to DNA damage is related to later tumor development in the rat azoxymethane colon carcinogenesis model. Carcinogenesis 22, 1831-1835, (2001)
Wali, R.K., et al., Inhibition of O6-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats. Carcinogenesis 20, 2355-2360, (1999)
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